Bob S replied: "There is no known cure for rheumatoid arthritis. However, many different types of treatment can be used to alleviate symptoms and/or to modify the disease process.
The goal of treatment in this chronic disease must be two-fold: to alleviate the current symptoms, and to prevent the future destruction of the joints and resulting handicap if the disease is left unchecked. These two goals may not always coincide: while pain relievers may achieve the first goal, they do not have any impact on the long-term consequences. For these reasons, most authorities believe that most RA should be treated by at least one specific anti-rheumatic medication, also named DMARD (see below), to which other medications and non-medical interventions can be added as needed.
Cortisone therapy has offered relief in the past, but its long-term effects have been deemed undesirable.[18]. However, cortisone injections can be valuable adjuncts to a long-term treatment plan, and using low dosages of daily cortisone (e.g., prednisone or prednisolone, 5-7.5 mg daily) can also have an important benefit if added to a proper specific anti-rheumatic treatment.[citation needed]
Pharmacological treatment of RA can be divided into disease-modifying antirheumatic drugs (DMARDs), anti-inflammatory agents and analgesics.[19][20] DMARDs have been found to produce durable remissions and delay or halt disease progression. In particular they prevent bone and joint damage from occurring secondary to the uncontrolled inflammation. This is important as such damage is usually irreversible. Anti-inflammatories and analgesics improve pain and stiffness but do not prevent joint damage or slow the disease progression.
There is an increasing recognition amongst rheumatologists that permanent damage to the joints occurs at a very early stage in the disease. In the past the strategy used was to start with just an anti-inflammatory drug, and assess progression clinically and using X-rays. If there was evidence that joint damage was starting to occur then a more potent DMARD would be prescribed. Tools such as ultrasound and MRI are more sensitive methods of imaging the joints and have demonstrated that joint damage occurs much earlier and in more sufferers than was previously thought. People with normal X-rays will often have erosions detectable by ultrasound that X ray could not demonstrate.
There may be other reasons why starting DMARDs early is beneficial as well as prevention of structural joint damage. In the early stage of the disease, the joints are increasingly infiltrated by cells of the immune system that signal to one another and are thought to set up self-perpetuating chronic inflammation. Interrupting this process as early as possible with an effective DMARD (such as methotrexate) appears to improve the outcome from the RA for years afterwards. Delaying therapy for as little as a few months after the onset of symptoms can result in worse outcomes in the long term. There is therefore considerable interest in establishing the most effective therapy with early arthritis, when they are most responsive to therapy and have the most to gain.[21]
Treatment also includes rest and physical activity. Regular exercise is important for maintaining joint mobility and making the joint muscles stronger. Swimming is especially good, as it allows for exercise with a minimum of stress on the joints. Heat and cold applications are modalities that can ease symptoms before and after exercise. Pain in the joints is sometimes alleviated by oral ibuprofen or other anti-inflammatory. Other areas of the body, such as the eyes and lining of the heart, are treated individually. However, there is no diet that has been shown to alleviate rheumatoid arthritis, although fish oil may have anti-inflammatory effects."
Audrey K replied: "Cellcept is mostly used for organ transplant patients, in order for the body not to reject the newly transplanted organ. Cellcept works by stopping a particular white blood cell (lymphocytes) from attacking the new organ. It does suppress the immune system and RA is an auto-immune disease, however it is a touchy regimen and the patient needs to follow the doctor's instructions to the absolute letter.
Side effects can be mild to severe, depending on the individual; from acne, constipation to abdominal pain, chest pain and difficulty breathing."
Is there anyone taking CellCept? If so, how long did you take it and what symptoms did you have? SERIOUS REPLIES ONLY. THANKS!
Hi, I was diagnosed with lupus almost 2 years ago after over 11 years of dealing with various symptoms and flares and kidney disease. Right now I am only taking 1/2 a 250 mg chloroquine tablet once a day but I still have pain and fatigue and my sed rate is going up slowly, which it does during seasonal changes. My doctor wants me to start chemo or steroids, which scares the crap out of me. I saw online that there is something called CellCept that may work to reduce lupus symptoms that may have more tolerable symptoms than chemo, but I don't want to jump into anything. Can someone who has lupus who has or is using CellCept tell me if it works, how long it works, if you experienced any really bad side effects and if so did you recover? And did the lupus come back? Thank you for your help.
DaBoomvang replied: "Hi
I do not have Lupus, but I do have a similar auto-immune disease. I can imagine we take the same drugs for the same reasons, because our auto-immune systems are out of controll and need to be supressed,
I have been taking methotrexate (aka chemo), and it's been absolutely horrible. The side effects of nausea and vomiting were miserable. Plus, I was sooooo tired. I would sleep for 18 hours, get up, and need a nap within 2 hours.
Just today, I am starting a new medication... Cellcept!
I am hoping for the best. I dont know what to expect. I dont know what side effects to expect either. I can let you know though!
The worst drug I've ever had to take though, was prednisone (steropids). I would recommend you do ANYTHING to avoid taking it! I gained 20 pounds in weeks on it, and it was not because of over eating! The drug makes you gain weight. AND... it redistributes your fat into your belly - so now I have a beer belly. :o( I gained 3 inches in my waistline. Dieting wont help - there is nothing you can do to avoid it.
I wish you the best as you battle your fight! I hope you fight the fight! Good luck,"
mgnysgtcappo replied: "My wife has been taking cellcept for her Lupus for the last two and a half years with little side effects. She was a little sick to her stomach at first but now it really doesn't affect her. It has done wonders for her Lupus flare ups though. She hasn't had kidney involvement since being on the drug and she is only taking 5 mg of prednisone right now. She also has antiocardiolipid syndrome and takes coumadin to thin her blood. If you have any more questions or would like some more detailed info please feel free to email me"
Adverese side effects of generic cellcept.? I am a kidney transplant patient. Has any one using cellcept and then going to the generic form had any negative side effects/ FDrom the Generic Equivalent Drug!
kelly d replied: "generic drugs are the same as brand, its exactly the same ingredient that is going to make you feel better"
any one out there that use cellcept? any sideeffects for you and has it help you eczema? anyone who has eczema as bad as I what do you use for makeup and have been using steroids forever
Diamond-Diva32 replied: "2-points"
are there any lupus patients who have used alternative methods to treat there lupus with good results? I have lupus and fibromaralya. I,ve had many different symptons thru the years. I had to stop taking steroids for it, because I developed osteperosis I also take plaquinall and cellcept. Any info you can give me is appreciated kitkatz
JustMe replied: "The following all natural supplements are very effective in treating Lupus.
GLA Complex: nature's steroid - VERY IMPORTANT FOR LUPUS
Vita-C: antioxidant; also anti-inflammatory
B-Complex: strengthens glandular functions; nourishes nervous system
Alfalfa Complex: anti-inflammatory; strengthens kidneys
Optiflora: for the immune system
Zinc Complex: protects skin and organs; promotes healing
Carotomax: powerful antioxidant
Garlic Complex: immune system enhancer; protects enzyme systems
Vitamin E + Selenium: helps the body use oxygen more efficiently; promotes healing
Hope this is helpful and feel free to contact me with questions
or if interested in the brand."
My mum has MS and her doctor has now given her Cellcept to take (but this is for transplant patients)??? I have no idea why he has given her this as the side affects are so terrible it can only make her worst. Plus the only thing I can find about it is nothing to do with MS (multiple sclerosis). Has anyone had any experience of using this?
♥♥The Queen Has Spoken♥♥ replied: "Drugs are often used "off label," or for disorders they are not actually approved for.
Cellcept is an immunosupressive drug. And believed to help therapy work better."
gracerecvd replied: "MS is one of many autoimmune diseases. One of the first lines of treatment for these disorders is a medication used for patients undergoing chemotherapy for cancer - methotrexate. I don't find it odd at all that the doctor prescribed a medication that is an autoimmune suppressant. Although the side effects of the medications used in treating autoimmune diseases can be harsh, the untreated disease would be far worse. Understanding more about the underlying disease process of MS may make it easier to understand the tactics being employed by her doctor. But, if you still question the doctor's approach, don't hesitate to seek a second opinion (or third, or forth)."
ann l replied: "HELLO MY NAME IS ANN. I HAVE HAD RELAPSE, REMITTING MS (RRMS) FOR 7 YEARS. I HAVE TAKEN AVONEX, BESTONE, STERIODS AND NOTHING HELPED.
ABOUT A YEAR AGO, A FRIEND GAVE ME PAPERWORK ON LDN AND MS SHE PRINTED FROM THE COMPUTER. THIS MEDICINE HAS NOT BEEN APPROVED YET. MY PRIMARY DR. PRESCRIBED IT FOR ME AFTER I TOLD HIM I WAS AN ACOHOLIC. LDN IS USED FOR ALCOHOL, DRUGS, AIDS AND SEVERAL OTHER DISEAESES.
IT HAS BEEN A BLESSING TO ME. I'M LEARNING TO WALK AGAIN AND DO THINGS I HAVEN'T DONE IN SEVERAL. LOOK UP LDN AND MS. YOU'LL BE SURPRISED.
SOME FOLKS IT TAKES LONGER, DEPENDING ON THEIR IMMUNE SYSTEM. THE LDN BUILDS YOUR ENDORPANES IN YOUR BRAIN.
PASS THIS ON. THERE ARE SO MANY IT HAS HELPED.
GOD BLESS YOU AND YOURS,
ANN"
merka2t1 replied: "No, I cant say Ive heard of that drug before. i,as well, have MS. Ive been put on copaxone. There are alot of new drugs out there, maybe thats one of them. If the effects are so great, she should ask about avonex or copaxone-which are the top two drugs. Copaxone, has the least effects. Theres nothing worse than having MS and having horrible side affects from a drug thats supposed to help you. Please take care and good luck. Talk to the doctor and find other medicines."
Taking anabolic steroids if you have lupus? Hey everyone well heres my question I have tried every other type of protein,cretein, working out even with a trainer and nothing has really worked for me, I have lupus and am taking cellcept medidcation, I just recently got off of prendazone? I was just wondering if it is a bad idea to take (winstrol the steriod i plan on using) if I have lupus or while I am on this medication.
Black Coffee Blues replied: "I think it's a bad idea full stop mate. Steroids can really mess with your body and mind. The people that say they're ok and that 'everyone does them' aren't necessarily right. You have to weigh up the pro's and con's on your own - and even without an auto-immune disease they'd be a bad idea imo.
I'd suggest you google it and look for 'bad experiences' as they can teach you more. Like scientists seek to 'disprove' their own theory in order to check it out. You should do the same. Don't try and prove it's ok for you to do that. Try and prove that it 'isn't' ok. That's the way to get the most realistic and reliable answer that you're looking for."
Linda R replied: "Don't play with fire!!!!!! Your immune system is already screwed up because of the lupus. This is a question for your rheumatologist, but I think you already know the answer.
So, you can build this buff body using the anabolic steroids, it will look lovely in your coffin."
havent been to the neuro in a few months but has anyone who is dealing with myasthenia gravis? heard of any breakthrough in the cure. a friend of mine had written me and told me that their mom heard they had a breakthrough, but i am the one who is battling it and i havent heard of any new drug or cure or anything. all besides the normal drugs used which i tried them all, prednisone, mestinon, cellcept, thymectomy, imuran cyclosporine, plasmapheresis, and ivig. anything i missed? i am sure open for a treatment to help me get better
Diane D replied: "I haven't heard of anything either, but your neurologist should be up on the latest treatments."
drrajeshchauhan2 replied: "I am happy for you as you seem to be keeping quite abreast with the latest on your condition. That is real good and would be helping you also. Here are a few sites where you can read more of the condition and one of the sites is enrolling volunteers for new clinical trials. Good luck.
"
fasttrack replied: "A controlled clinical trial has never been reported for any medical or surgical modality used to treat myasthenia gravis. All recommended regimens are empirical and experts disagree on treatments of choice. Treatment decisions should be based on knowledge of the natural history of disease in each patient and the predicted response to a specific form of therapy. Treatment goals must be individualized according to the severity of disease, the patient's age and sex, and the degree of functional impairment. The response to any form of treatment is difficult to assess because the severity of symptoms fluctuates. Spontaneous improvement, even remissions, occur without specific therapy, especially during the early stages of the disease."
I want to ask from mgnysgtcappo lupus question.? my wife is also on cellcept since 8 months, but and having no heart problems, but suffering lupus nephritis, and creatnine is 3.2, and having pain in kidneys, just to know that for how long did wife used immunosuppressive cellcept/myfortic. and that is she get well because of Rituxan, if yes how much she has taken per day and for how long.
Rituxan= /day/ months/years?
cellcept 500mg= /day/months/years?
is she on prednisolone now, how much she is taking?
your information will help my wife treatment
Regards.
Stephanie replied: "You arent going to like this answer but it changed my life. Read a book called You Are WHat You Eat by Gillian Mc Keith so your wife can one day be healthy again. It really does work if you follow her 11 week plan. Its not about losing weight its about being healthy."
mgnysgtcappo replied: "HI Falcon,
My wife has used Cellcept (now using Myfortic...Cellcept's time released cousin) for the last 4 years. We went off Cellcept for a year. Off Cellcept her creatine has been as high as 9+. Currently her creatine is in the normal range, hovering around 0.8 to 0.9.
I truly believe that Rituxan saved her life. Cellcept is great for maintenance but when her kidney numbers spiraled out of control, nothing seemed to bring her back. We tried Cytoxan which is the old stand by for Lupus Nephritis but it didn't work...actually seemed to worsen everything because it made her weaker.
The cool thing about Rituxan is that it targets the B Cells so the side effects are much more limited, ie..no vomiting, hair loss, loss of appetite, etc.
She had four treatments and will have another in a couple of months. Rituxan is an IV chemotherapy agent 500 mg one time per week for four weeks. Another dose at one year to seal the deal.
As far as prednisone...she is now completely off it for the first time in 15 years. She had been on maintanence steroids to keep the flares down but since the Rituxan she hasn't had to take it. Unfortunately it came a little too late as she has suffered necrosis of her femur due to the prednisone.
She is on the equivalent of 2 grams (2000 mg) of Cellcept a day...Myfortic is titrated differently so she takes 1300 mg a day of Myfortic which equals 2000 mg of Cellcept.
Just as in Cellcept there are no long term studies for Rituxan. All I can give is our allegorical evidence that it works. When in dire times you have to try anything. I am so glad that we did.
Please....anything that you need...contact me. I will do my best to answer and help out. We've been battling this disease for a long time and will share all the info we have.
Good luck and take care!"
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