Entropy replied: "Yes, of course. These are powerful prescription drugs and should be taken only as prescribed. Klonopin is the trade name for the drug clonazepam, a benzodiazepine, which is of the same family as roofies and is a powerful sedative. This activates GABA channels in your nervous system, which inhibits neural activity - basically turning down neural activity in your entire brain. It is typically used for treatment of seizure disorders and as an anti-anxiety drug. This drug has a very dangerous cumulative effect with other "downers", including alcohol. Too much of this will cause you to lapse into a coma and eventually stop breathing/heart beating. Wellbutrin is the molecule buproprion, an SSRI that blocks the reuptake of particular neurotransmitters associated with pleasure and anti-anxiety. It seems to be a "not so SSRI" though since it blocks reuptake of dopamine and norepinephrine as well (the mechanism of cocaine action). This was pulled as an anti-anxiety drug since it seems to cause seizures pretty effectively (and not paying attention to the dosage in the case of misuse will definitely increase your chances). In using this drug you also risk lapsing into a psychotic episode and has also been reported to be pretty toxic to your liver at high doses. Taking both of these drugs in conjuction will be extremely dangerous since one is an upper and another a downer. Read about speedballs if you want to know the risks. It's like pulling a rubber band in both directions, eventually it will snap. The anti-anxiety effects of these drugs will probably stack and you will have very low inhibitions. I will state it again. Prescription drugs are designed to have a very specific therapeutic window and/or route of administration. Taking it by an unintended route and unprescribed dose places you at incredible risk for bodily harm. A great example is people who think aspirin is innocuous because it's over the counter. Aspirin is also very liver toxic at high doses and accidental overdose is the leading cause of liver failure in this country at the moment."