Do you have any ideas for me? First, please don't answer if you are not a Doctor or other health provider. Holistic is fine also. Conditions: 5' 10" - 320 pound male (While I know the weight is a huge factor, please do not hound on it. That has been explored at nauseum) Poor Circulation – Limbs and other body parts will go to sleep quickly if compressed. Couldn’t sit Indian style for 2 minutes to save my life. Chronic Shortness of Breath under physical strain. Chest pains can occur occasionally under the same stressors. High Blood Pressure - Only become a problem 6 months ago Cholesterol - Problem whole adult life. Have dropped it from 300 to 191 in the last 6 months on medication. Type II Diabetic - Non-insulin, but heading there fast. – Diagnosed 2 Years ago – With Metformin, sugar hovered around 125 until about 3 months ago. Now it fluctuates through the 200s. See new meds below. They are helping, but not allot. Bi-Polar - Have been under medical and psychological care for years. Medicines not helping like they used to. Possible additional neurological disorder. I base this on ticks, twitches and other neurological deficits I experience. My Father had M.S. Died 3 years ago at 62 years of age. He finally threw in the towel and let a UTI take him. He was sick with it for about 30 years. My father's youngest brother has M.S. also and is still alive, but in poor physical shape do to the disease. Unlike my father, he has resisted treatment. My father’s was relapsing remitting M.S. and his I believe his brother’s was secondary progressive. I had a brain MRI done 12 months and no lesions were found. I have avoided the LP due to having one 20 years ago and it being an experience that I do not wish to repeat. The Dr. butchered it so badly I ended up in the hospital. Also, my dad’s and uncle’s was inconclusive, but they obviously had the disease Current Symptoms: Binge Eating Insomnia Loss of Memory and Cognitive Function – Minor to Moderate depending on the task. I am a college educated adult. Was once at the top of my field and now cannot hold a job. See below. Headaches Pain in Legs and occasional swelling – Especially at night. Manic and depressed on a regular basis. – Usually manic at night and depressed during day, which leads to the insomnia. Sleeping pills help, but make me hung-over in the morning. I do not like taking them. Take an occasional Ambien. Ability to interact with others outside of immediate family varied. Usually will respond to most folks in an upbeat and cheery manor. I’ve been in sales and customer service for 20 years. But, when pressured, I resort to depressed, withdrawn and angry. Has caused me not to be able to hold down a full time job for more than a couple of months at a time. I am not ever violent, but I become very agitated and argumentative to the point where others do not want to work with me. Other info: I avoid alcohol except at an occasional party. I rarely drink to excess. Maybe two or three times a year. I have not and have never done illegal drugs. I have an addictive personality and have always known where illegal drugs would take me. Mentioning that, I have always been a big risk taker. Money, pain and the like. I have limited physical exercise, due to shortness of breath and poor circulation. I enjoy working out, it just hurts to much. To see me on the street, you would not suspect most of this stuff, except of course the obesity. Med List: Lamictal - 300mg once daily - Taken for 4 years at variable doses. Wellbutrin XL - 150mg once daily - Taken off and on for about 5 years. Prozac - 60mg - once daily - Taken for 1 year. Lorezapam - 0.5mg - once daily - Taken for 1 year Simvastatin - 40mg – once daily – Taken for 6 months Metoprolol - 100mg - once daily -Taken for 6 months Metformin - 1000mg twice daily - Taken for 2 years at this dose Actos - 15mg - Just started last week. Glipizide - 10mg - once daily Herbals Cinnamon - 3000mg daily Walgreens Diabetic Vitamin Pack - Two many items to list. Taken daily. I know this is a ton of information, but I need someone to look at the whole picture. My Drs just treat symptoms and never seen to get to the root of the problem. They are excellent Drs; one Harvard Educated, but like my father I just think they don’t know what to do with me. Also, please no lectures about putting this stuff on an unsecured site. I could care less who reads this. I want to get better. I want to be productive again.